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KMID : 0613820210310121088
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Journal of Life Science
2021 Volume.31 No. 12 p.1088 ~ p.1093
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Characterization of Myostatin Gene Variants in Jeju Horses
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Choi Jae-Young
Shin Kwang-Yun
Lee Jong-An
Shin Sang-Min
Kang Yong-Jun
Shin Moon-Cheol
Cho In-Cheol
Yang Byoung-Chul
Kim Nam-Young
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Abstract
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Jeju horse (Equus ferus caballus) is a Korean horse breed that has been native to Jeju Island for a long time. Jeju horses are used as racehorses, and their racing ability is a major economic trait. The role of the myostatin (MSTN) gene in skeletal muscle mass has been studied in various mammals, and mutations in the MSTN gene are known to affect the racing ability and stamina of thoroughbreds. In this study, we compared the frequency of mutations in the MSTN gene in several horse breeds, including 1,433 Jeju horses. Among the mutations (ECA18 g.66493737C>T) in the MSTN gene, the long-distance aptitude genotype (TT) was found to have a frequency of 0.826 in Jeju horses, which was higher than that in Halla horses (0.285) and thoroughbreds (0.252). The genotypes and arrival records of Jeju horses were compared according to various distances (400 m, 800 m, 900 m, 1,000 m, 1,110 m, and 1,200 m). According to the results, the CT type showed a faster-reaching record than the TT type in races of less than 1,000 m. However, almost identical results were confirmed in races over 1,110 m. This study suggests that the MSTN mutation in Jeju horses may be related to race distance aptitude. In future research, the data in this study can be used for developing markers related to race distance aptitude and racing abilities in Jeju horses.
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KEYWORD
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Halla horses, Jeju horse, MSTN, polymorphism, Thoroughbred
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